INTRODUCTION |
Procardis is a European Commission Framework 6 (FP6)
funded project which exploits advances in complex trait genetics and
functional genomics to discover novel susceptibility genes for
coronary artery disease (CAD). PROCARDIS is incorporating a
definitive genome-wide association analysis and measurement of novel
intermediate phenotypes to yield biomarkers for CAD risk and
quantitative traits for genetic analysis.
|
CHALLENGE |
| Cardiovascular mortality and morbidity in Europe which
represents 1/3 to 1/2 of overall mortality rates hardly needs to
be underlined. Two well recognised general features characterise
the cardiovascular mortality figures within Europe, of which CAD
accounts for between 1/3 and 2/3: a great inter-country
variability, with decreasing East-West and North-South
gradients, and a falling prevalence in the Western and Southern
countries contrasting the stable/increasing rates in many
Eastern countries. The need for targeted studies with the aim of
exploring the specific interaction between genetic and
environmental risk factors is recognised as a priority. |
|
AIMS |
-
identify novel proteins and pathways implicated in
atherosclerosis and arterial thrombosis
-
define new targets for prevention and treatment
-
devise diagnostic
tools
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FUNDING |
 The
Procardis project is funded with 10 million Euros
through the 6th Framework Program of the European
Union (LSH-2005-2.1.1-1). The project is aimed to
integrate the efforts of key European basic and
clinical scientists into one cohesive effort. It started in
Apr 2007 and will run for 4 years. |
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